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. Author manuscript; available in PMC: 2024 Oct 8.
Published in final edited form as: Cell Rep. 2024 Jul 18;43(8):114518. doi: 10.1016/j.celrep.2024.114518

Figure 1. Design of stabilizing mutations in SOSIP and IDL trimers.

Figure 1.

(A) Representation of the stabilizing disulfide bonds in SOSIP trimers (intersubunit bond between residues 501 in gp120 and 605 in gp41) and IDL trimers (in-trasubunit bond between residues 113 and 429, in the inner and outer domains, respectively, of the same gp120 subunit) highlighted on individual gp120/gp41 protomers.

(B) Schematic representation of SOSIP and IDL trimers from the BG505 Env (clade A) showing the respective disulfide bonds and the most salient sequence features.