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. Author manuscript; available in PMC: 2024 Oct 8.
Published in final edited form as: Cell Rep. 2024 Jul 18;43(8):114518. doi: 10.1016/j.celrep.2024.114518

Figure 5. Cryo-EM structure of the HIV-1 JR-FL IDL Env trimer in complex with Fab PGT122.

Figure 5.

(A) Cryo-EM sensity is shown for HIV-1 Env JR-FL IDL bound to PGT122 Fab.

(B) Illustration of the trimer structure.

(C) Illustration and stick representation of the engineered disulfide bond.

(D) Volume density is shown in blue mesh and clearly resolved around the disulfide linkage shown in (C).

(E) Overall alignment of gp120 and gp41 IDL (gray and black) compared to SOSIP (pink and maroon, PDB: 5FYK). Illustrations of Env trimers are shown with bound Abs hidden.

(F) The region of disulfide stabilization in SOSIP trimers is shown contrasted with the structure we present colored as in (E), with density as blue mesh.

See also Figures S5 and S7 and Table S1.