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. Author manuscript; available in PMC: 2024 Oct 8.
Published in final edited form as: Cell Rep. 2024 Jul 18;43(8):114518. doi: 10.1016/j.celrep.2024.114518

Figure 7. The BG505 IDL trimer displays a prevalent native-like conformation.

Figure 7.

(A) Three-state Gaussian-distributed FRET population histogram (mean ± SD) of the BG505 IDL trimer, reflecting the conformational distribution sampled by the trimers.

(B) Conformational landscape of the BG505 IDL Env trimer (A) overlaid with those of virus-associated, full-length BG505 Env and BG505 SOSIP trimer.33

(C) Conformational distribution of the double mutant BG505 SOSIP + IDL Env trimer as in (A).

(D) Conformational landscape of the BG505 SOSIP + IDL SOSIP (C) overlaid with those of virus-associated, full-length BG505 Env and BG505 SOSIP trimer.33 Parameters and statistics for the smFRET analysis are provided in Table S2.