TABLE 2.
Summary of data on PAN of PR8
| MAb | Antigenic site | N50 (nM)
|
Inhibition of internalization | Inhibition of fusion | Inhibition of hemolysis | Inhibition of prefusion intermediate | Inhibition of exposure of low-pH epitopes | Inhibition of gain in protease sensitivity at low pH | |
|---|---|---|---|---|---|---|---|---|---|
| IgG | Fabc | ||||||||
| H36 | Sb | 22 | 78 (3.6) | No | Yes | Yes | Yes | No | No |
| H37 | Ca2 | 58 | 1,060 (18.3) | No | Yes | Yes | Yes | No | NDb |
| H9 | Cb | 340 | 4,400 (12.9) | No | Yesa | Yesa | Yes | No | ND |
a
H9 Fab inhibited fusion to a plateau of approximately 80%; the others inhibited fusion completely. Columns 4 to 7 summarize the activity of all IgGs and Fabs, and columns 8 and 9 show the activity of the Fabs only.
b
ND, not done.
c
Values in parentheses are Fab N50/IgG N50 ratios.