TABLE 3.
Comparison of the binding of MAbs to pH-sensitive epitopes in the prefusion intermediate (pH 5 and 4°C) or the densensitized (pH 5 and 37°C) form of the HA of PR8 virus to the pH 7.5 forma
MAbb | Binding to pH 5, 4°C virus/pH 7.5 virus | Binding to pH 5, 37°C virus/pH 7.5 virus |
---|---|---|
Y8 | 14.0 | 25.0 |
H2 | 3.4 | 5.4 |
H3 | 2.0 | 5.4 |
H18 | 3.2 | 6.0 |
H17 | 0.5 | 0.16 |
Data from Fig. 9.
The epitopes of MAbs Y8, H2, H3, and H18 are exposed, and the epitope of H17 is reduced at low pH.