Table 1.
Pathway GO annotations and targets of Drosophila lncRNA:CR33942 and mir-8. LncRNA:CR33942 and mir-8 can interact with and regulate multiple signalling pathways and target multiple components in a pathway (Figure 4B). The mechanism of action can be captured using GO terms from the MF aspect (column 1), the pathway regulation GO terms from the BP aspect (column 2). The targets and their roles are shown in column 3 and the reference (PMID) in column 4.
| ncRNA gene|mechanism | Pathway GO term (ID) | Target gene|role | Ref |
|---|---|---|---|
| lncRNA:CR33942|NF-kappaB binding (GO:0051059) | positive regulation of Toll signalling pathway (GO:0045752) |
Dif|transcription factor dl|transcription factor |
[64] |
| lncRNA:CR33942|transcription coactivator activity (GO:0003713) | positive regulation of peptidoglycan recognition protein signalling pathway (GO:0061059) | Rel|transcription factor | [43] |
| mir-8|mRNA base-pairing translational repressor activity (GO:1903231) | negative regulation of Toll signalling pathway (GO:0045751) |
Tl|receptor dl|transcription factor |
[67] |
| mir-8|mRNA base-pairing translational repressor activity (GO:1903231) | negative regulation of Notch signalling pathway (GO:0045746) | Ser|receptor ligand | [68] |
| mir-8|mRNA base-pairing translational repressor activity (GO:1903231) | negative regulation of epidermal growth factor receptor signalling pathway (GO:0042059) | spi|receptor ligand | [69] |
| mir-8|mRNA base-pairing translational repressor activity (GO:1903231) | negative regulation of canonical Wnt signalling pathway (GO:0090090) |
wls|ligand biogenesis pan|transcription factor |
[70] |
| mir-8|mRNA base-pairing translational repressor activity (GO:1903231) | positive regulation of insulin receptor signalling pathway (GO:0046628) | ush|transcription factor | [71] |
| mir-8|mRNA base-pairing translational repressor activity (GO:1903231) | positive regulation of hippo signalling (GO:0035332) |
yki|transcription factor sd|transcription factor |
[72] |