A, Individual assessment timelines through the duration of the study, with most participants assessed multiple times. B, Recruitment of new participants has occurred in a pulsatile fashion, depending on commencement of discrete major sub-studies. C, Assessments have been continuous, however, as efforts are made to continually track existing participants (with recent interruptions due to COVID-19). D, Survival curves showing the study duration of Parkinson’s participants: ongoing recruitment is required to balance drop-outs due to mortality and other factors. Figure available under an open CC-BY licence (MacAskill 2022).