TABLE 2.
Summary of polymyxin MICs for strains used in the in vivo studies
| Strain | Mutation | COL MIC (mg/L) in MHII | COL MIC (mg/L) in MHII + NaHCO3 | PMB MIC (mg/L) in MHII | PMB MIC (mg/L) in MHII + NaHCO3 |
|---|---|---|---|---|---|
| HUMC1 | Wild type | 0.5 | 1 | <0.125 | <0.125 |
| LAC-4 WT | Wild type | 0.5 | 2 | <0.125 | <0.125 |
| LAC-4 ColR | pmrA | >64 | 2 | 8 | <0.125 |
| AR-0307 | Unknown | >64 | 1 | 8 | 0.25 |
| AR-0308 | Unknown | 8 | 0.5 | 4 | <0.125 |
| 1112707 | Unknown | 16 | 0.5 | 4 | <0.125 |
| 1184244 | Unknown | 64 | 1 | 16 | <0.125 |
| 1124614 | Unknown | 32 | 0.5 | 8 | <0.125 |
| 1180013 | Unknown | >64 | 1 | 8 | <0.125 |
| 1174913 | Unknown | 32 | 1 | 8 | 0.5 |