Fig 12.

Compound 1 reduces SARS-CoV-2 viral load and live virus titer in SARS-CoV-2 Omicron-infected SGH. (A–H) Representative H&E staining of lung tissue of SARS-CoV-2 Omicron-infected SGH treated with vehicle (A–B, E–F) or compound 1 (C–D, G–H). Images are from two representative SGHs per condition, with magnification at 1× (A–D) and 20× (E–H). (I) RT-qPCR of genomic RNA (E gene) from lung tissue from vehicle (VHC), 1, and PF-332-treated SGH. (J) RT-qPCR of sub-genomic RNA (N gene) from VHC, 1, and PF-332-treated SGH. (K) SARS-CoV-2 viral titer in lung tissue of VHC and 1-treated SGH.