TABLE 2.
Mouse PD datab
| Regimen | Observations | SUPER drug | SUPER drug doses (mg/kg) | Data type | Data source | Treatment duration (days) |
|---|---|---|---|---|---|---|
| Initial | ||||||
| Paa | 235 | Pa | 6.25, 10, 12.5, 25, 30, 50, 100, 200, 300, and 600 | Mouse CFU/lung | JHU | 14–63 |
| PaM | 84 | Pa | 50, 100 | Mouse CFU/lung | JHU (9) | 56 |
| PaZ | 92 | Pa | 50, 100 | Mouse CFU/lung | JHU (9) | 112 |
| PaMZ | 202 | Pa | 25, 50, 100 | Mouse CFU/lung | JHU (9) | 56 |
| Ba | 75 | B | 12.5, 25,50 | Mouse CFU/lung | JHU | 79 |
| BPaM | 93 | B | 25 | Mouse CFU/lung | JHU (13) | 84 |
| BPaZ | 101 | B | 25 | Mouse CFU/lung | JHU (13) | 28 |
| BPaMZ | 77 | B | 25 | Mouse CFU/lung | JHU (13) | 28 |
| Relapse | ||||||
| PaMZ | 100 | Pa | 50, 100 | Mouse CFU/lung | JHU (9) | 3, 4 |
| BPaZ | 15 | B | 25 | Mouse CFU/lung | JHU (9) | 3, 4 |
| BPaMZ | 10 | B | 25 | Mouse CFU/lung | JHU (9) | 3, 4 |
a
Data and PK-PD model have previously been described in Ernest et al. (11).
b
Doses of M and Z are 100 and 150 mg/kg, respectively.