TABLE 3.

Clinical PK models used for simulations

Drugs	PK structure model	Study	Simulated doses	References
B	3-cmt model with transit absorption	NC-005 Bloading	400 mg once daily for days 1–14, 200 mg three times per week for days 15–56	Svensson et al. (14)
		NC-005 Bdaily	200 mg once daily for 56 days
		NC-008 B[200/100]	200 mg once daily for 56 days, then 100 mg once daily for 63 days
Pa	1-cmt model with transit absorption and dose-dependent absorption, bioavailability, and volume	NC-002, NC-006	100 or 200 mg daily for 56 days or 119 days	Salinger et al. (15)