TABLE 5.

Mouse PK/PD models parameter in fast replicating, slow replicating bacteria, and relapse phase using monotherapy and combinations^a

Drug regimen	SUPER drug	Parameter	Value	Relative standard error	Unit	SUPER drug fraction unbound ratio of human vs mouse
B	B	E max	0.515	0.007	day−1	1.0 (24)
		EC50	0.228	0.0027	mg/L
BPaZ	B	EC50	0.151	0.008	mg/L
		E max	0.515	FIX	day−1
		K net	0.0044	1.43	day−1
BPaM	B	EC50	0.7928	0.00005	mg/L
		E max	0.515	FIX	day−1
		K net	0.0126	1.52	day−1
BPaMZ	B	EC50	0.00000226	0.0324	mg/L
		E max	0.690	0.0208	day−1
		K net	0.0052	0.930	day−1
Pa	Pa	EC50	3.46	0.00306	mg/L	0.71 (25, 26)
		E max	0.429	0.00122	day−1
		γ	0.374	0.0121
PaZ	Pa	EC50	0.0765	0.0033	mg/L
		E max	0.604	0.00666	day−1
PaM	Pa	EC50	0.526	0.000108	mg/L
		E max	0.429	FIX	day−1
		γ	2.309	0.00007
PaMZ	Pa	E max	0.406	0.000411	day−1
		EC50	0.0724	0.000820	mg/L
		K net	0.0492	0.366	day−1

^a E_max, maximum rate of bacterial kill per day; EC50, the concentration of drug required to reach 50% of the maximum rate of bacterial kill per day; K_net, the net growth rate of bacterial after treatment has ended; γ, the Hill coefficient determining the steepness of the exposure response curve.