Table 5.

Risk of incident HF with a high hsCRP (≥2 mg/L) at baseline visit

	Hazard ratio (95% confidence interval)	p-value
Overall HF
Unadjusted	1.24 (0.99 to 1.56)	0.07
Model 1	1.28 (1.01 to 1.62)	0.038
Model 2	1.08 (0.84 to 1.38)	0.55
HFrEF
Unadjusted	1.01 (0.71 to 1.42)	0.98
Model 1	1.14 (0.80 to 1.62)	0.48
Model 2	1.07 (0.74 to 1.55)	0.72
HFpEF
Unadjusted	1.62 (1.13 to 2.32)	0.008
Model 1	1.59 (1.10 to 2.29)	0.013
Model 2	1.22 (0.84 to 1.79)	0.30

Model 1= Age + sex

Model 2= Model 1 + systolic blood pressure, antihypertensive medication, BMI, diabetes status, eGFR, smoking history, CHD history, cholesterol-HDL-C ratio, and statin medication

The above values are presented as adjusted hazard ratios (HR) per 1 standard deviation (SD) increase of the hsCRP level (on a log2 scale)

HF = Heart failure; HFpEF = Heart failure preserved ejection fraction; HFrEF = Heart failure reduced ejection fraction; hsCRP = high sensitivity C-reactive protein