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. 2024 Oct 7;22:605. doi: 10.1186/s12951-024-02883-w

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 8 — Transcriptomic analysis. A A volcano plot of the FA-PFNB-SIRP α siRNA + US and PBS group. B, C Gene ontology annotation analysis (B) and Kyoto Encyclopedia of Genes and Genomes pathway analysis (C) in the FA-PFNB-SIRP α siRNA + US group. D Heat map illustrating differential gene expression of macrophages (M1 and M2) and natural killer cell-mediated cytotoxicity. E, F Heat map depicting differential expression of antigen processing and presentation-related genes (E) and T cell functional markers (F). G Venn diagram illustrating differentially expressed genes positively regulating both innate and adaptive immune responses. H Functional networks of differentially expressed immune-related genes regulating both innate and adaptive immune responses