Appendix Table A1.
MEDLINE Search Strategy
| Search No. | Search Terms | Search Notes | Results |
|---|---|---|---|
| S1 | Anterior Cruciate Ligament/ | MeSH | 11,660 |
| S2 | “anterior cruciate ligament*” | 24,973 | |
| S3 | ACL OR ACLR | 19,613 | |
| S4 | 1 OR 2 OR 3 | 29,234 | |
| S5 | Blood/ | MeSH | 53,764 |
| S6 | Blood OR bloods | 3,997,776 | |
| S7 | Plasma/ | MeSH | 24,156 |
| S8 | Plasma | 984,856 | |
| S9 | Serum/ | MeSH | 11,184 |
| S10 | Serum | 1,163,613 | |
| S11 | Urine/ | MeSH | 37,942 |
| S12 | Urine | 381,615 | |
| S13 | Synovial fluid/ | MeSH | 13,528 |
| S14 | “synovial fluid*” | 18,724 | |
| S15 | Biomarkers/ | MeSH | 324,330 |
| S16 | Biomarker* | 693,576 | |
| S17 | CTX-2 | 183 | |
| S18 | Matrix metalloproteinases/ | MeSH | 10,592 |
| S19 | “matrix metalloproteinases” OR MMp | 68,354 | |
| S20 | TNF-related apoptosis-Inducing Ligand/ | MeSH | 5929 |
| S21 | TNF | 199,434 | |
| S22 | Interleukins/ | MeSH | 18,120 |
| S23 | Interleukin* | 386,929 | |
| S24 | Cartilage Oligomeric Matrix Protein/ | MeSH | 793 |
| S25 | “cartilage oligomeric matrix protein” OR COMP | 4648 | |
| S26 | Transforming Growth Factor beta/ OR Transforming growth factor beta1/ OR Latent TGF-beta Binding Proteins/ | MeSH | 64,016 |
| S27 | TGF | 82,006 | |
| S28 | Tissue Inhibitor OR Metalloproteinases/ | MeSH | 3600 |
| S29 | “tissue inhibitor or metalloproteinases” OR TIMP | 14,688 | |
| S30 | NTX | 2279 | |
| S31 | ARGS | 3065 | |
| S32 | Interferons/ | MeSH | 24,838 |
| S33 | Interferons OR IFN | 152,113 | |
| S34 | OR/5-33 | ||
| S35 | 4 AND 34 | 3670 | |
| S36 | 35 not (Animals/ not (Animals/ and Humans/)) | MEDLINE human studies filter | 2834 |
| S37 | Limit 36 to English language | 2617 |