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Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1980 Mar;33(3):262–268. doi: 10.1136/jcp.33.3.262

Microscopic amyloid deposits in the heart valves: a common local complication of chronic damage and scarring.

Y Goffin
PMCID: PMC1146050  PMID: 7381025

Abstract

The presence of amyloidosis was detected in 33 out of 213 (15.5%) mitral and aortic valves that had been surgically removed for chronic valvular disease. No correlation could be found with age or type of valvular disease, neither was there any clinical evidence of an associated generalised amyloidosis. Histologically, the amyloid deposits were microscopic and restricted to areas of dense scar tissue. No comparable alterations were found in 147 unaltered valves which served as controls. The term 'dystrophic' is proposed to describe this particular form of valvular amyloidosis.

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Selected References

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  1. BENSON R., SMITH J. F. Cardiac amyloidosis. Br Heart J. 1956 Oct;18(4):529–543. doi: 10.1136/hrt.18.4.529. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Buja L. M., Khoi N. B., Roberts W. C. Clinically significant cardiac amyloidosis. Clinicopathologic findings in 15 patients. Am J Cardiol. 1970 Oct;26(4):394–405. doi: 10.1016/0002-9149(70)90736-8. [DOI] [PubMed] [Google Scholar]
  3. DAHLIN D. C. Primary amyloidosis, with report of six cases. Am J Pathol. 1949 Jan;25(1):105–123. [PMC free article] [PubMed] [Google Scholar]
  4. FREDERIKSEN T., GOTZSCHE H., HARBOE N., KIAER W., MELLEMGAARD K. Familial primary amyloidosis with severe amyloid heart disease. Am J Med. 1962 Sep;33:328–348. doi: 10.1016/0002-9343(62)90230-9. [DOI] [PubMed] [Google Scholar]
  5. JONES R. S., FRAZIER D. B. Primary cardiovascular amyloidosis; its clinical manifestations, pathology and histogenesis. Arch Pathol (Chic) 1950 Sep;50(3):366–384. [PubMed] [Google Scholar]
  6. Pomerance A. The pathology of senile cardiac amyloidosis. J Pathol Bacteriol. 1966 Apr;91(2):357–367. doi: 10.1002/path.1700910209. [DOI] [PubMed] [Google Scholar]
  7. SYMMERS W. S. Amyloidosis; five cases of primary generalized amyloidosis and some other unusual cases. J Clin Pathol. 1956 Aug;9(3):212–228. doi: 10.1136/jcp.9.3.212. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. SYMMERS W. S. Primary amyloidosis: a review. J Clin Pathol. 1956 Aug;9(3):187–211. doi: 10.1136/jcp.9.3.187. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Schwartz P. Uber Amyloidose als Manifestation und Ursache der präsenilen und senilen Degeneration. Fortschr Med. 1976 May 20;94(15):890–896. [PubMed] [Google Scholar]
  10. Shirahama T., Cohen A. S. High-resolution electron microscopic analysis of the amyloid fibril. J Cell Biol. 1967 Jun;33(3):679–708. doi: 10.1083/jcb.33.3.679. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Westermark P., Natvig J. B., Johansson B. Characterization of an amyloid fibril protein from senile cardiac amyloid. J Exp Med. 1977 Aug 1;146(2):631–636. doi: 10.1084/jem.146.2.631. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Wright J. R., Calkins E., Breen W. J., Stolte G., Schultz R. T. Relationship of amyloid to aging. Review of the literature and systematic study of 83 patients derived rom a general hospital population. Medicine (Baltimore) 1969 Jan;48(1):39–60. [PubMed] [Google Scholar]
  13. Wright J. R., Calkins E., Humphrey R. L. Potassium permanganate reaction in amyloidosis. A histologic method to assist in differentiating forms of this disease. Lab Invest. 1977 Mar;36(3):274–281. [PubMed] [Google Scholar]

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