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. 2024 Sep 10;27(10):110919. doi: 10.1016/j.isci.2024.110919

Figure 1.

Figure 1

Taste response to sugar, but not fatty acids, is reduced at intermediate concentrations in aging and AD model flies

(A) Proboscis extension response (PER) was measured in female flies after 24 h of starvation. Either sucrose or hexanoic acid was applied to the fly’s labellum for a maximum of 2 s and then removed to observe proboscis extension reflex.

(B) There is a significant effect of age on PER to sucrose in w1118 flies (two-way ANOVA: F1,278 = 23.77, p < 0.0001; n = 20–30).

(C) Expression pattern of Gr64f is visualized with GFP. Gr64f-expressing neurons project to the subesophageal zone of the brain. Background staining is NC82 antibody (magenta). Scale bar: 100 μm.

(D) There is a significant effect of Arctic expression on PER to sucrose (two-way ANOVA: F2,702 = 7.529, p < 0.0006; n = 28–49).

(E) There is no effect of age on PER to hexanoic acid in w1118 flies (two-way ANOVA: F1,415 = 0.2959, p < 0.5867; n = 20–40).

(F) There is no effect of Arctic expression on PER to hexanoic acid (two-way ANOVA: F2,671 = 0.0396, p < 0.9612; n = 30–40). Data are represented as mean ± SEM. ∗p < 0.05; ∗∗p < 0.01.