FIG. 7.
Schematic diagram of cdc2 regulation and activity in the uninfected (top) and HSV-1-infected (bottom) cell. In uninfected cells, cdc2 is inactivated by wee-1 and myt-1 kinases and activated by cdc25C phosphatase, cyclin-dependent activating kinase (CAK), and association with cyclin B at the G2/M interphase. HSV-1 infection targets wee-1 and cdc25C through the actions of ICP22 and UL13, and UL42 associates with cdc2. The substrates for cdc2 in infected cells include ICP0, ICP4, and gI. The activation of cdc2 in the infected cell is associated with optimal accumulation of a subset of γ2 proteins exemplified by Us11 protein.