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The ASFV pI7L can inhibit the IFN-γ-triggered JAK-STAT signaling pathway by targeting STAT1. pI7L interacts with STAT1 and inhibits the phosphorylation and homodimerization of STAT1 depending on the tyrosine at position 98 as well as the nuclear translocation of STAT1. Created with BioRender.com.
