Table 1.
Efficacies of antibiotics on cell viability between normoxia and hypoxia.
| Spectrum | Name | Efficacy | |||
|---|---|---|---|---|---|
| Normoxia (21% O2) | Hypoxia (1% O2) | ||||
| Con. (µg/mL) | Efficacy (%) | Con. (µg/mL) | Efficacy (%) | ||
| Quinolones | Ciprofloxacin | 50 | 10.00 ± 2.36 | 50 | 9.27 ± 2.26** |
| 100 | 33.49 ± 1.22*** | 100 | 10.07 ± 2.91** | ||
| 150 | 38.87 ± 3.99*** | ||||
| 200 | 42.62 ± 1.71*** | ||||
| Cephalosporins | Ceftizoxime | 500 | 21.77 ± 2.19*** | No effect | |
| 1000 | 22.61 ± 2.93*** | ||||
| Tetracyclines | Minocycline | 10 | 15.98 ± 2.48*** | 50 | 4.42 ± 0.3* |
| 50 | 12.13 ± 1.91** | ||||
| Aminoglycosides | Netilmicin | No effect | No effect | ||
Efficacies of 4 different antibiotics on improving cell viability under normoxic (21% O2) and hypoxic (1% O2) conditions at 48 hours of incubation with each antibiotic are presented. “Efficacy (%)” indicates a percentage for cell viability of group by treated antibiotics compared to the control group.
*
P < .05.
**
P < .01.
***
P < .001.