. 2024 Jul 22;114(10):950–957. doi: 10.1159/000540205

Table 1.

Patient clinical characteristics and year of diagnosis

Patient	Biochemical analysis	Pituitary imaging	IPSS	TPS	Pathology	Gamma-knife radiosurgery	Bilateral adrenalectomy
2010-1	UFC, ODST, SeC, SaC, ACTH, LDDST	Microadenoma	No	Yes	ACTH adenoma	No	No
1	UFC, ODST, SeC, SaC, ACTH, LDDST	Microadenoma	No	Yes	ACTH adenoma	No	No
2010-1	UFC, ODST, SeC, HDDST	Not seen	Yes	Yes	Normal	No	No
2	UFC, ODST, SeC, HDDST	Not seen	Yes	Yes	Normal	No	No
2012-1	UFC, ODST, SeC, ACTH, LDDST, Dex-CRH	Microadenoma	No	Yes	ACTH adenoma	No	No
3	UFC, ODST, SeC, ACTH, LDDST, Dex-CRH	Microadenoma	No	Yes	ACTH adenoma	No	No
2012-1	UFC, ODST, SeC, ACTH, LDDST, Dex-CRH	Macroadenoma (extracellular invasion)	No	Yes	ACTH adenoma	Yes	Yes
4	UFC, ODST, SeC, ACTH, LDDST, Dex-CRH	Macroadenoma (extracellular invasion)	No	Yes	ACTH adenoma	Yes	Yes
2012-1	UFC, ODST, SeC, ACTH, LDDST, Dex-CRH	Not seen	Yes	Yes	No tissue	No	Yes
5	UFC, ODST, SeC, ACTH, LDDST, Dex-CRH	Not seen	Yes	Yes	No tissue	No	Yes
2013-1	UFC, ODST, SeC, SaC, ACTH, LDDST, Post-CRH	Not seen	Yes	Yes	ACTH adenoma	No	No
6	UFC, ODST, SeC, SaC, ACTH, LDDST, Post-CRH	Not seen	Yes	Yes	ACTH adenoma	No	No
2013-1	UFC, ODST, SeC, ACTH	Macroadenoma (extracellular invasion)	No	Yes	ACTH adenoma	No	No
7	UFC, ODST, SeC, ACTH	Macroadenoma (extracellular invasion)	No	Yes	ACTH adenoma	No	No
2013-1	UFC, ODST, SeC, ACTH, LDDST, Dex-CRH	Not seen	Yes	Yes	ACTH adenoma	Yes	No
8	UFC, ODST, SeC, ACTH, LDDST, Dex-CRH	Not seen	Yes	Yes	ACTH adenoma	Yes	No
2014-2	UFC, ODST, SeC	Macroadenoma (extracellular invasion)	No	Yes	ACTH adenoma	Yes	No
9	UFC, ODST, SeC	Macroadenoma (extracellular invasion)	No	Yes	ACTH adenoma	Yes	No
2014-1	UFC, ODST, SeC, SaC, ACTH, LDDST, Dex-CRH	Microadenoma	Yes	Yes	ACTH adenoma	No	No
10	UFC, ODST, SeC, SaC, ACTH, LDDST, Dex-CRH	Microadenoma	Yes	Yes	ACTH adenoma	No	No
2014-2	UFC, ODST, SeC, SaC, ACTH, LDDST	Microadenoma	No	Yes	ACTH mixed adenoma	No	No
11	UFC, ODST, SeC, SaC, ACTH, LDDST	Microadenoma	No	Yes	ACTH mixed adenoma	No	No
2015-2	UFC, ODST, SeC, ACTH	Macroadenoma (extracellular invasion) (CT)	No	No	–	No	No
12	UFC, ODST, SeC, ACTH	Macroadenoma (extracellular invasion) (CT)	No	No	–	No	No
2015-2	UFC, ODST, SeC, SaC, ACTH, LDDST, Post-CRH	Not seen (CT)	Yes	Yes	ACTH mixed adenoma	No	No
13	UFC, ODST, SeC, SaC, ACTH, LDDST, Post-CRH	Not seen (CT)	Yes	Yes	ACTH mixed adenoma	No	No
2016-1	UFC, SeC, SaC, ACTH, ODST, LDDST	Microadenoma	Yes	Yes	ACTH mixed adenoma	No	Yes
14	UFC, SeC, SaC, ACTH, ODST, LDDST	Microadenoma	Yes	Yes	ACTH mixed adenoma	No	Yes
2016-1	UFC, ODST, SeC, ACTH, LDDST	Microadenoma	No	Yes	ACTH adenoma	No	No
15	UFC, ODST, SeC, ACTH, LDDST	Microadenoma	No	Yes	ACTH adenoma	No	No
2018-1	UFC, ODST, SeC, ACTH, LDDST, Dex-CRH	Microadenoma	No	Yes	ACTH adenoma	Yes	No
16	UFC, ODST, SeC, ACTH, LDDST, Dex-CRH	Microadenoma	No	Yes	ACTH adenoma	Yes	No
2019-2	ODST, SeC, ACTH, LDDST	Macroadenoma (extracellular invasion)	No	Yes	ACTH adenoma	No	No
17	ODST, SeC, ACTH, LDDST	Macroadenoma (extracellular invasion)	No	Yes	ACTH adenoma	No	No

First column includes: year of diagnosis, 1: female, 2: male and patient number.

IPSS, inferior petrosal sinus sampling; TPS, transsphenoidal surgery; UFC:24-h urinary free cortisol; ODST, overnight dexamethasone test; SeC, serum cortisol; SaC, salivary cortisol; LDDST, low-dose dexamethasone test; HDDST, high-dose dexamethasone test; Post-CRH, CRH stimulation test; Dex-CRH, CRH stimulation test in continuation of LDDST; ACTH adenoma, tissue with ACTH overproduction defined.