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. Author manuscript; available in PMC: 2024 Oct 8.
Published in final edited form as: Sci Transl Med. 2024 Feb 14;16(734):eadk4266. doi: 10.1126/scitranslmed.adk4266

Fig. 3. Pulmonary vascular compliance determines pVAD utility for left ventricular function.

Fig. 3.

Shown is the degree of benefit achieved across pVAD speed sweeps for the left ventricle in relation to pulmonary vascular compliance at each of the states modeled in the animals. Left ventricular benefit was measured by changes in (A) left ventricular end-diastolic volume (P < 0.001), (B) left ventricular maximum pressure slope, dP/dtmax (P < 0.05), (C) left ventricular afterload, determined by systemic arterial elastance (P < 0.05), (D) left ventricular stroke volume (P < 0.01), and (E) left ventricular stroke work (P < 0.01). N = 21 complete pVAD speed sweeps. Corresponding curves and the square of the multiple correlation coefficient are denoted for correlations of statistical significance, determined by P value < 0.05.