Table 1.
Permeability values of the agents selected on BBB in vitro model. Data < 0.2 × 10−6 cm/s indicates inadequate absorption with bioavailability < 1%, data between 0.2 and 2 × 10−6 cm/s indicates 1–90% bioavailability, and data > 2 × 10−6 cm/s shows over 90% bioavailability.
| Substances | Time | |||
|---|---|---|---|---|
| 4 hr | 6 hr | 12 hr | 24 hr | |
| φ Green tea | 0.22 x 10−6 | 0.33 x 10−6 | 0.76 x 10−6 | 0.46 x 10−6 |
| Saffron | 0.24 x 10−6 | 0.29 x 10−6 | 0.65 x 10−6 | 0.48 x 10−6 |
| Citicoline | 0.2 x 10−6 | 0.28 x 10−6 | 0.58 x 10−6 | 0.44 x 10−6 |
| γ φ Trans-R | 0.2 x 10−6 | 0.34 x 10−6 | 0.83 x 10−6 | 0.53 x 10−6 |
| ∗γ φ ψ MIX | 0.47 x 10−6 | 0.72 x 10−6 | 1.18 x 10−6 | 0.94 x 10−6 |
The abbreviations are the same as those used in Figure 2. All agents are p < 0.05 vs. control; ∗p < 0.05 vs. green tea; γp < 0.05 vs. saffron; φp < 0.05 vs. citicoline; ψp < 0.05 vs. trans-R.