Table 2.
Cell composition IMP.
| P1 | P2 | P3 | P4 | P5 | P6 | P7 | P8 | P9 | median | ||
|---|---|---|---|---|---|---|---|---|---|---|---|
| % of CD45+ | CD3+ | 99.6 | 99.5 | 98.5 | 99.7 | 99.5 | 99.5 | 99.5 | 99.5 | 99.5 | 99.5 |
| NKT | 1.6 | 2.1 | 3.8 | 3.9 | 2.6 | 6.2 | 6.0 | 6.6 | 4.5 | 3.9 | |
| CD4+ | 74.2 | 81.7 | 68.4 | 68.0 | 75.4 | 62.2 | 53.7 | 75.8 | 75.2 | 74.2 | |
| CD8+ | 22.5 | 14.9 | 24.9 | 27.2 | 20.8 | 29.5 | 36.9 | 16.1 | 19.0 | 22.5 | |
| Monocytes | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
| B cells | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
| CD56+ CD16+ cells | 0.1 | 0.1 | 1.0 | 0.0 | 0.1 | 0.2 | 0.2 | 0.1 | 0.1 | 0.1 | |
| CAR+ cells (% of CD3+) | 43.3 | 36.4 | 51.9 | 58.1 | 53.9 | 34.4 | 38.3 | 61.2 | 51.5 | 51.5 | |
| % of CAR+ | CAR+CD4+ | 86.5 | 89.4 | 86.0 | 79.4 | 82.2 | 75.7 | 64.9 | 83.2 | 83.1 | 83.1 |
| CAR+CD8+ | 11.7 | 9.4 | 12.4 | 19.5 | 16.6 | 22.0 | 30.2 | 12.2 | 15.9 | 15.9 | |
| CAR+CD4+ CD8+ | 1.7 | 1.1 | 1.5 | 1.1 | 1.2 | 2.2 | 4.6 | 4.5 | 1.0 | 1.5 | |
| CAR+ CD4- CD8- |
0.1 | 0.1 | 0.1 | 0.1 | 0.1 | 0.2 | 0.3 | 0.1 | 0.1 | 0.1 |