Table 2.
MIC (µg/mL) of tested antifungals against C. Neoformans var. Grubii (H99) ATCC 208821 in 384-well NBS plates, by OD570 − 600 readout with resazurin (n = 4). # amphotericin B prepared from solution stock, * literature MICs for 5-flucytosine against C. neoformans are not strain specific.
| Antifungal | Inhibition of C. neoformans ATCC 208821 | ||
|---|---|---|---|
| MIC (µg/mL) | |||
| RPMI 48 h | YNB 36 h | CLSI or Literature | |
| Ketoconazole | 0.031 | 0.5-2 | 0.0632 |
| Posaconazole | ≤ 0.0005–0.008 | 0.03 | 0.06333 |
| Itraconazole | 0.031 | 0.031 | 0.0632 |
| Fluconazole | 4->16 | 4->16 | 4-833,34 |
| Voriconazole | 0.008 | 0.03 | .00233 |
| Anidulafungin | > 16 | > 16 | > 835 |
| Caspofungin | > 16 | > 16 | > 1636 |
| Micafungin | > 16 | > 16 | > 1637 |
| Amphotericin B | 0.125, 0.016# | 0.25, 0.5# | 134 |
| 5-Flucytosine | 0.25–0.5 | 0.125 | 0.125-8*38 |