Table 1. Effect of bafilomycin A1 on the timing of delivery.
| Group | PRG22 |
PRG23 |
PRG24 |
No delivery | ||||
|---|---|---|---|---|---|---|---|---|
| Day of treatment | Drug | am | pm | am | pm | am | pm | |
| Intact | 2 | 42 | 129 | 3 | 2 | 0 | 0 | |
| PRG15 | vehicle | 0 | 1 | 13 | 3 | 1 | 0 | 1 |
| Baf A1 125 pg | 2 | 1 | 2 | 1 | 0 | 0 | 1 | |
| Baf A1 625 pg | 0 | 6 | 8 | 0 | 3 | 0 | 0 | |
| PRG19 | vehicle | 0 | 0 | 0 | 3 | 0 | 0 | 0 |
| Baf A1 125 pg | 0 | 0 | 4 | 3 | 0 | 0 | 0 | |
| Baf A1 625 pg | 0 | 1 | 4 | 0 | 0 | 0 | 0 | |
For PRG15 or PRG19, mother rats were administered a single dose (200 μl/ovary) of bafilomycin A1 (Baf A1, 62.5 or 312.5 pg/ovary, in total 125 or 625 pg/rat) or vehicle intraovarian-bursally, and were examined for the timing of delivery from PRG22 through PRG25 at 0900 h or 1800 h each day. Data from intact rats were obtained from ordinary breeding of laboratory rats over the last several years.