Fig. 2.

Baseline systolic and diastolic cardiac function in WT and SGLT2 KO mice, before surgery. All of the parameters are measured 2 days before TAC/DOCA surgery. A, The ratio of early diastolic mitral inflow velocity to late diastolic mitral inflow velocity (E/A ratio). B, The ratio of early diastolic mitral inflow velocity to early diastolic mitral annulus velocity (E/e' ratio). C, Ejection fraction (EF). D, Fractional shortening (FS). E, Heart rate (HR). F, Stroke volume (SV). G, Cardiac output (CO). H, Left atria internal diameter end diastole (LAIDd). I, Left ventricle mass (LV mass Cor). J, Aortic root diameter. Data are presented as mean ± SD. ns: not significant. WT-B, wild-type baseline (n = 18; 9 M (male), 9F (female)), KO-B, SGLT2 KO baseline (n = 24; 10 M/14F). A–F and H–J: unpaired t test; G: Mann–Whitney test. B: Baseline