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. 2024 Jul 24;119(5):751–772. doi: 10.1007/s00395-024-01067-9

Fig. 8.

Fig. 8

Nitric oxide synthase (NOS) inhibition abolished HF protection by EMPA. A The ratio of early diastolic mitral inflow velocity to late diastolic mitral inflow velocity (E/A ratio) measured at 10 days after TAC/DOCA surgery. B The ratio of early diastolic mitral inflow velocity to early diastolic mitral annulus velocity (E/e' ratio) measured at 10 days after TAC/DOCA surgery. C Left atria internal diameter end diastole (LAIDd) measured at 10 days after TAC/DOCA surgery. D Ejection fraction (EF) measured at 10 days after TAC/DOCA surgery. E Fractional shortening (FS) measured at 10 days after TAC/DOCA surgery. F Left ventricle mass (LV mass Cor) measured at 10 days after TAC/DOCA surgery. G Left ventricle weight to tibia length(LV/tibia). H, Left atria weight to tibia length (LA/tibia). I, Lung wet/dry ratio (Lung w/d ratio). J, Liver wet/dry ratio (Liver w/d ratio). Data are presented as mean ± SD. * p < 0.05, *** p < 0.001, **** p < 0.0001. ns: not significant. A-K: HF-KO-CO (n = 8; 3 M/5F), HF-KO-CO-NA (n = 8; 4 M/4F) and HF-KO-EM-NA (n = 8; 4 M/4F). A-J: One-way ANOVA with Holm-Šídák's multiple comparisons test

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