Fig. 2.

3D Mechanistic ABM for neuronal growth. Panel a shows the agent-based discretization and the early stage of a neuron simulation (pyramidal cell). The center is the spherical soma (cell body). The dendrites are discretized with small, cylindrical agents. Typically, the tips drive the growth (Shree et al. 2022); hence, we differentiate between the general and tip agents. The agents define a tree-like structure with different segments and branches. b Pyramidal cell at the end of the simulation. c Experimental pyramidal cell in the mouse hippocampus observed by Benavides-Piccione et al. (2019) ( NMO_147071)