Fig. 5. Cryo-EM structures of BA.2.86/JN.1 spikes in complex with ACE2.
a Cryo-EM structure of the BA.2.86 spike in complex with ACE2. Two perpendicular views of BA.2.86 spike-ACE2 are depicted as surface, with ACE2 in cornflower blue and the trimeric spike in pink, medium purple, and purple. b Structure of BA.2.86 RBD-ACE2. c Cryo-EM structure of the JN.1 spike in complex with ACE2. Two perpendicular views of JN.1 spike-ACE2 are depicted as surface, with ACE2 in cornflower blue and the trimeric spike in orange, gold, and pale violet. d Structure of JN.1 RBD-ACE2. e Detailed interactions between the BA.2.86 spikeL455-ACE2 and the local refinement cryo-EM maps. f Detailed interactions between the JN.1 spikeS455-ACE2 and the local refinement cryo-EM maps. g Comparation of the RBD-ACE2 interface region in other recent variants: WT RBD-ACE2(PDB:6LZG), XBB.1 RBD-ACE2(PDB:8IOV), EG.5.1 RBD-ACE(PDB:8XLN).