Figure 1.

Retinal signaling pathways in mice significantly affected by (A) imposed negative defocus (LIM vs control), and (B) the same, combined with application of atropine eye drops for 4 weeks after minus-lens induction for 2 weeks (atropine-treated LIM vs LIM), with (C) the respective z-scores of each newly identified signaling pathway in both groups. The x-axis represents statistical significance, and the y-axis represents pathway categories. Each bubble represents a signaling pathway, and the numbers inside the bubbles indicate the same signaling pathways in A and B. The colors of the bubbles indicate their relative effects on the signaling pathways that were significantly affected by the experimental treatment—from low activation (pink) to high activation (orange); from low inhibition (light blue) to high inhibition (dark blue); and no net activity (gray).