Table 3B. Schedule of events; treatment period.

	Treatment Period
	Month 1 - weekly visits								Month 2 - fortnightly visits								Month 3 - fortnightly visits
	Week 1 Mon/Thu		Week 2 Mon/Thu		Week 3 Mon/Thu		Week 4 Mon/Thu		Week 1 Mon/Thu		Week 2 Mon/Thu		Week 3 Mon/Thu		Week 4 Mon/Thu		Week 1 Mon/Thu		Week 2 Mon/Thu		Week 3 Mon/Thu		Week 4 Mon/Thu
Time window (+/- days)	2	2	2	2	2	2	2	2	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3
Verbal consent	X		X		X		X				X				X				X				X
Examination	X		X		X		X				X				X				X				X
Vital signs	X		X		X		X				X				X				X				X
AE screening	X		X		X		X				X				X				X				X
Urinary bHCG (as appropriate)	X
12-lead ECG	X						X
Laboratory safety assessments	X		X		X		X				X				X				X				X
Diagnostic sampling				X
Treatment initiation					X
Vitual volunteer diary	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X
Self-collected photograph	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X	X
PBMC collection	X		X		X		X				X				X				X				X
Serum collection	X		X		X		X				X				X				X				X
Microbiology blood sampling	X		X		X		X				X				X				X				X
Faecal microbiome sampling	X						X								X								X
Skin swabs	X						X				X				X				X				X
DLQI and GAD-7 questionnaires	X		X		X		X		X								X
Time (min)	120	10	60	10	240	10	60	10	15	10	60	10	15	10	60	10	15	10	60	10	15	10	60	10