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. 2024 Sep 6;46:100457. doi: 10.1016/j.ahjo.2024.100457

Table 1.

Definition of formulas and categories for FIB-4 measures and associated risk factors.

Name Formula
FIB-4 score calculation FIB-4 = [age (years) x AST (IU/L)] / platelet count (109/L) x [ALT (IU/L)]1/2
FIB-4 categories low (<1.30) intermediate (1.30- < 2.67)
high (2.67- < 3.25) very high (≥3.25)
Diabetes Status Pre-diabetes:
Meets one or more of the following criteria:
  • 1.

    Fasting glucose = 100–125 mg/dL

  • 2.

    HbA1c 5.7- < 6.5 %
Diabetes:
Meets at least one of the following criteria:
  • 1.

    Fasting glucose ≥126 mg/dL

  • 2.

    Non-fasting glucose ≥200 mg/dL

  • 3.

    HbA1c >6.5 %

  • 4.

    Taking insulin

  • 5.

    Taking medication to lower blood sugar

  • 6.

    Self-reported DM

Weight Normal weight: BMI < 25 kg/m3
Overweight: 25 ≤ BMI < 30 kg/m3
Obese: BMI ≥ 30 kg/m3
Hypertension Meets one or more of the following criteria:
  • 1.

    Blood pressure ≥ 130/80 mmHg

  • 2.

    Taking medication for high blood pressure
Metabolic syndrome Meets three or more of the following criteria:
  • 1.

    Waist circumference > 88 cm for females or > 102 cm for males

  • 2.

    Triglyceride levels ≥150 mg/dL

  • 3.

    HDL-C < 50 mg/dL for females and < 40 mg/dL for males

  • 4.

    Fasting glucose ≥100 mg/dL, taking insulin, or taking other diabetes medication

  • 5.

    Blood pressure ≥ 130/85 mmHg or on antihypertensive medication


Based on Alberti KG, et al. Circulation 2009;120(16):1640–5. PMID: 19805654.
Non-alcoholic fatty liver disease Meets the following criteria:
  • 1.

    ALT levels >20 U/L in women or >30 U/L in men

  • 2.

    Has metabolic syndrome (with the exclusion of hepatitis B, hepatitis C, or alcoholism)
Excessive alcohol consumption Meets at least one of the following criteria:
  • 1.

    Underage drinking: any alcohol use under the age of 21

  • 2.

    Heavy drinking: 15 or more drinksa per week for men and 8 or more drinks per week for women

  • 3.

    Binge drinking: 5 or more drinks on one occasion for men and 4 or more drinks on one occasion for women

  • 4.

    Pregnant drinking: any alcohol consumed by pregnant women
a

A drink is defined in NHANES III as a glass or can of beer, glass of wine, shot of hard liquor or mixed drink. https://wwwn.cdc.gov/nchs/data/nhanes3/manuals/mecint.pdf.