Table 5.
Hazard ratio of cardiovascular and all-cause mortality according to FIB-4 groups stratified by metabolic status, NHANES III.
| Total (n = 13,326; 146.7 M) |
NAFLD (n = 640; 6.7 M) |
Obesity (n = 3365; 32.2 M) |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cardiovascular mortality (unadjusted) | ||||||||||||
| FIB-4 (by risk groups) | None | Pre-DM | DM | Total | None | Pre-DM | DM | Total | None | Pre-DM | DM | Total |
| Low | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref |
| Intermediate | 3.17‡ (9.32–18.62) |
4.21‡ (3.02–5.87) |
3.21‡ (2.21–4.65) |
8.43‡ (6.86–10.34) |
5.20† (1.75–15.49) |
1.80 (0.34–9.64) |
1.78 (0.73–4.32) |
3.08† (1.37–6.94) |
12.51‡ (5.66–27.65) |
2.69† (1.51–4.79) |
2.18† (1.32–3.62) |
5.07‡ (3.59–7.15) |
| High / Very High | 14.01‡ (5.63–34.90) |
8.76‡ (3.66–20.95) |
0.89 (0.22–3.53) |
8.81‡ (4.61–16.84) |
N/A | 7.07† (3.48–210.3) |
1.15 (0.11–12.40) |
2.81† (2.39–68.66) |
N/A | 5.54 (0.45–68.01) |
2.81 (0.51–15.48) |
4.83⁎ (1.14–20.5) |
| Cardiovascular mortality (adjusted) | ||||||||||||
| FIB-4 (by risk groups) | None | Pre-DM | DM | Total | None | Pre-DM | DM | Total | None | Pre-DM | DM | Total |
| Low | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref |
| Intermediate | 1.00 (0.15–6.51) |
0.80 (0.59–1.07) |
1.24 (0.70–2.22) |
1.05 (0.82–1.35) |
0.31 (0.03–2.78) |
0.85 (0.23–3.18) |
0.46 (0.12–1.71) |
0.55 (0.24–1.27) |
2.42 (0.94–6.22) |
0.69 (0.36–1.32) |
0.90 (0.36–2.22) |
1.03 (0.66–1.59) |
| High / Very High | N/A | 1.71 (0.84–3.46) |
0.58 (0.15–2.19) |
1.34 (0.74–2.42) |
0.03 (0.00–15.98) |
4.11 (0.75–22.34) |
0.45 (0.12–1.67) |
1.55 (0.47–5.15) |
N/A | 2.45 (0.18–33.84) |
0.78 (0.18–3.44) |
1.35 (0.42–4.37) |
| All-cause mortality (unadjusted) | ||||||||||||
| FIB-4 (by risk groups) | None | Pre-DM | DM | Total | None | Pre-DM | DM | Total | None | Pre-DM | DM | Total |
| Low | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref |
| Intermediate | 8.30‡ (6.90–9.97) |
4.16‡ (3.51–4.93) |
2.41‡ (1.94–3.00) |
6.42‡ (5.67–7.27) |
4.61† (1.76–12.11) |
3.15⁎ (1.33–7.48) |
1.38 (0.58–3.30) |
2.76‡ (1.75–4.36) |
5.59‡ (3.89–8.03) |
3.85‡ (2.92–5.06) |
1.51 (0.98–2.31) |
4.01‡ (3.23–4.99) |
| High / Very High | 15.63‡ (9.36–26.11) |
5.46‡ (3.16–9.43) |
2.07 (0.90–4.74) |
9.12‡ (6.22–13.38) |
N/A | 8.30⁎ (1.03–66.72) |
2.04† (1.26–3.29) |
5.87† (1.78–19.33) |
6.77⁎ (1.17–39.30) |
6.90† (1.71–27.90) |
2.85‡ (1.99–4.09) |
6.53‡ (4.38–9.75) |
| All-cause mortality (adjusted) | ||||||||||||
| FIB-4 (by risk groups) | None | Pre-DM | DM | Total | None | Pre-DM | DM | Total | None | Pre-DM | DM | Total |
| Low | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref | Ref |
| Intermediate | 1.07 (0.87–1.30) |
1.04 (0.90–1.20) |
0.93 (0.70–1.24) |
1.03 (0.91–1.17) |
0.40 (0.09–1.73) |
3.10 (0.81–11.77) |
0.27† (0.11–0.65) |
0.97 (0.64–1.47) |
1.04 (0.70–1.52) |
1.23 (0.80–1.87) |
0.69 (0.39–1.22) |
0.98 (0.74–1.29) |
| High / Very High | 1.91⁎ (1.07–3.41) |
1.36 (0.93–1.98) |
1.26 (0.63–2.53) |
1.66† (1.20–2.31) |
N/A | 5.56⁎ (1.01–30.75) |
0.65 (0.28–1.54) |
0.91 (0.34–2.47) |
2.31 (0.42–12.71) |
3.26 (0.95–11.18) |
1.14 (0.70–1.86) |
2.10⁎ (1.19–3.71) |
Adjusting for age, sex, ethnicity, BMI, non-HDL-C, HDL—C, systolic and diastolic BP, cigarette smoking, and alcohol use.
⁎
p < 0.05.
†
p < 0.01.
‡
p < 0.0001.