The authors have found that the published version of the article contained an error in Figure 4 and Supplementary Table S4. We have mislabelled the patients P31, P32, and P33 as P29, P30, and P31, respectively. These mistakes affected the patient labellings for the DNS at NSP9 35, Spike 440, and Spike 450. The original and corrected figures and tables are shown below. The errors were introduced during drafting of the manuscript, and do not affect the results, interpretation, and conclusion. This update does not affect the main text, and other parts of the publication. The authors apologize for any inconvenience caused by these errors.
Original version:
Corrected version:
The original and corrected patient numbers for the affected protein DNS residue in Supplementary Table S4:
| Protein | Amino acid residue | Original patient number | Corrected patient number |
|---|---|---|---|
| NSP3 | 977 | P30 | P32 |
| NSP9 | 35 | P29 | P31 |
| NSP9 | 35 | P30 | P32 |
| NSP9 | 35 | P31 | P33 |
| S | 440 | P31 | P33 |
| S | 450 | P30 | P32 |
| S | 450 | P31 | P33 |
The corrected Supplementary Table S4 is shown below.
| Protein | Amino acid residue | VOC/VOI with this substitution as lineage-defining mutation (Date of designationa) | Patient number | 1st sequence with the respective substitutionc |
|---|---|---|---|---|
| NSP3 | 977 | Gamma (VOC: 2021-01-11) | P4 | July 2022 |
| P13 | September 2021 | |||
| P32 | October 2022 | |||
| NSP5 | 90 | Beta (VOC: 2020-12-18) | P9 | September 2021 |
| P10 | 2020 | |||
| P23 | March 2021 | |||
| NSP9 | 35 | EG.5 (VOI: 2023-08-09) BA.2.86 (VOI: 2023-11-21) JN.1 (VOI: 2023-12-18) |
P9 | September 2021 |
| P31 | November 2022 | |||
| P32 | July 2022 | |||
| P33 | October 2022 | |||
| NSP12 | 671 | Delta (VOC: 2021-05-11) XBB.1.5 (VOI: 2023-01-11) XBB.1.16 (VOI: 2023-04-17) |
P4 | August 2022 |
| P9 | September 2021 | |||
| P31 | February 2023 | |||
| S | 484 | Beta (VOC: 2020-12-18) Gamma (VOC: 2021-01-11) Omicron (VOC: 2021-11-26) Eta (VOI: 2021-03-17) Theta (VOI: 2021-03-24) Kappa (VOI: 2021-04-04) Mu (VOI: 2021-08-30) Zeta (VOI: 2021-09-17) XBB.1.5 (VOI: 2023-01-11) XBB.1.16 (VOI: 2023-04-17) EG.5 (VOI: 2023-08-09) BA.2.86 (VOI: 2023-11-21) JN.1 (VOI: 2023-12-18) |
P1 | June 2020 |
| P2 | June 2021 | |||
| P5 | October 2020 | |||
| P6 | February 2021 | |||
| P8 | May 2020 | |||
| P12 | November 2020 | |||
| P13 | June 2021 | |||
| P22 | July 2020 | |||
| P24 | February 2021 | |||
| P26 | June 2021 | |||
| 490 | Lambda (VOI: 2021-06-14) XBB.1.5 (VOI: 2023-01-11) XBB.1.16 (VOI: 2023-04-17) EG.5 (VOI: 2023-08-09) |
P2 | June 2021 | |
| P5 | December 2020 | |||
| P7 | December 2021 | |||
| P8 | May 2020 | |||
| P9 | September 2021 | |||
| P12 | November 2020 | |||
| P18 | N/A | |||
| 95 | Iota (VOI: 2021-03-24) Mu (VOI: 2021-08-30) Omicron (VOC: 2021-11-26)b |
P2 | June 2021 | |
| P6 | October 2021 | |||
| P7 | November 2021 | |||
| P17 | November 2021 | |||
| P18 | N/A | |||
| 493 | Omicron (VOC: 2021-11-26)e | P1 | August 2020 | |
| P7 | June 2021 | |||
| P25 | May 2021 | |||
| P26 | March 2021 | |||
| 13 | Epsilon (VOI: 2021-03-05) | P2 | June 2021 | |
| P3 | August 2020 | |||
| P8 | May 2020 | |||
| 417 | Beta (VOC: 2020-12-18) Gamma (VOC: 2021-01-11) Omicron (VOC: 2021-11-26)d XBB.1.5 (VOI: 2023-01-11) XBB.1.16 (VOI: 2023-04-17) EG.5 (VOI: 2023-08-09) BA.2.86 (VOI: 2023-11-21) JN.1 (VOI: 2023-12-18) |
P5 | December 2020 | |
| P21 | July 2022 | |||
| P24 | October 2022 | |||
| 440 | Omicron (VOC: 2021-11-26)d | P1 | September 2020 | |
| P28 | January 2021 | |||
| P33 | November 2022 | |||
| 450 | BA.2.86 (VOI: 2023-11-21) JN.1 (VOI: 2023-12-18) |
P9 | September 2021 | |
| P32 | September 2022 | |||
| P33 | October 2022 | |||
| 655 | Gamma (VOC: 2021-01-11) Omicron (VOC: 2021-11-26) XBB.1.5 (VOI: 2023-01-11) XBB.1.16 (VOI: 2023-04-17) EG.5 (VOI: 2023-08-09) BA.2.86 (VOI: 2023-11-21) JN.1 (VOI: 2023-12-18) |
P7 | December 2021 | |
| P10 | 2020 | |||
| P21 | June 2022 | |||
| M | 82 | Eta (VOI: 2021-03-17) Delta (VOI: 2021-04-04, VOC: 2021-05-11) Kappa (VOI: 2021-04-04) |
P2 | June 2021 |
| P7 | March 2021 | |||
| P10 | 2020 | |||
| P26 | August 2021 |
Abbreviations: F, female; M, male; VOC, variants of concern; VOI, variants of interest.
The dates of designation for the VOI and VOC were referenced from WHO's “Historical working definitions and primary actions for SARS-CoV-2 variants” document: https://www.who.int/publications/m/item/historical-working-definitions-and-primary-actions-for-sars-cov-2-variants and https://www.who.int/activities/tracking-SARS-CoV-2-variants/previously-circulating-vois.
Only in BA.1.
The dates that appear before the designation of the corresponding VOC/VOI by the WHO are Indicated in bold face.
Only in BA.2, BA.4, and BA.5.
Only BA.1 and BA.2.