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. 2024 Sep 16;21(10):4983–4994. doi: 10.1021/acs.molpharmaceut.4c00339

Figure 2.

Figure 2

Apparent permeability (Papp) and ER determined in tissue with the Ussing chamber. A-to-B: apical to basolateral transport. B-to-A: basolateral to apical transport. Succeeded experiments per substrate are described by n = A-to-B/B-to-A. (A) Papp enalaprilat (paracellular transport) n = 9/10 pediatrics, n = 4/5 adults. (B) Papp propranolol (transcellular transport) n = 10 pediatrics, n = 5 adults. (C) ER enalaprilat with age, n = 8 pediatric, n = 4 adults. (D) ER propranolol with age, n = 9 pediatric, n = 4 adults. (E) Papp talinolol (P-gp transport) n = 9/10 pediatrics, n = 4/6 adults. (F) Papp rosuvastatin (BCRP transport) n = 10/10 pediatrics, n = 4/6 adults. (G) ER talinolol with age, n = 8 pediatric, n = 4 adults. (H) ER rosuvastatin with age, n = 9 pediatric, n = 4 adults.