Table 4.
Components of metabolic syndrome in the two groups at baseline and after 8 weeks
| Factor | Synbiotic + antipsychotic group (n = 27) |
Placebo + antipsychotic group group(n = 28) |
P a | Time and group interaction | |
|---|---|---|---|---|---|
| F | P-value c | ||||
| WC(cm( | |||||
| week 0 | 101.2  8.83 |
101.28 ± 11.69 | 0.903a | ||
| week 8 | 98.96 ± 7.63 | 104.32 ± 12.14 | 0.000b | 19.785 | 0.000 |
| Pb | 0.003 | 0.001 | |||
| HDL(mg/dl)* § | |||||
| Week 0 | 66(51–79) | 57(48–67) | 0.535a | ||
| Week 8 | 60(49–77) | 60(49–71) | 0.129b | 3.050 | 0.087 |
| Pb | 0.395 | 0.354 | |||
| TG(mg/dl) § | |||||
| Week 0 | 191(134–244) | 148(99–176) | 0.030a | ||
| Week 8 | 145(114–186) | 151(99–191) | 0.029b | 0.079 | 0.780 |
| Pb | 0.026 | 0.684 | |||
| FBS(mg/dl) § | |||||
| Week 0 | 100(87–109) | 96.50(90.25–104) | 0.926a | ||
| Week 8 | 95(89–103) | 97.50(89.50 -103.75) | 0.768b | 0.768 | 0.503 |
| Pb | 0.394 | 0.580 | |||
| SBP(mmHg) | |||||
| Week 0 | 134.73 ± 12.99 | 137.29 ± 14.69 | 0.498a | ||
| Week 8 | 127.85 ± 12.56 | 131.82 ± 13.01 | 0.251b | 0.232 | 0.632 |
| Pb | 0.000 | 0.045 | |||
| **DBP(mmHg) | |||||
| Week 0 | 84.64± 9.99 | 83.73 ± 14.07 | 0.160a | ||
| Week 8 | 82.92 ± 12.69 | 85.15± 11.00 | 0.140b | 3.223 | 0.079 |
| Pb | 0.559 | 0.616 |
Data are reported as mean ± SD for normally distributed variables and interquartile range for non-normal distribution
FBS: fasting blood sugar, TG: triglyceride, TC: total cholesterol, HDL-c: high-density lipoprotein cholesterol, SBP: systolic blood pressure, DBP: diastolic blood pressure WC: waist circumference
a: Obtained from the independent t-test for normally distributed variables /Mann-Whitney test for other variables
b:analysis of covariance adjusted for baseline values, smoking, education, and the change in energy intake for normally distributed variables and logHDL/ Mann-Whitney test for changes in serum levels of other variables
Pb: Obtained from the paired sample t-test for normally distributed variables and Wilcoxon test for non-normal variables
P-value c Obtained from repeated measures analysis of variance adjusted for smoking, education and the change in energy intake
* In the placebo group, the data of one patient whose baseline HDL-c was more than 150 mg/dL was excluded from the analysis
** Data of 4 patients were excluded from diastolic blood analysis because they were outliers
§ non-normally distributed variables