Table 5.

Biochemical parameters in the two groups at baseline and after 8 weeks

Factor	Synbiotic + antipsychotic group (n = 27)	Placebo + antipsychotic group group(n = 28)	P a	Time and group interaction
				F	P-value c
TC(mg/dl)
Week 0	187.66 ± 35.20	162.92 ± 26.65	0.005a
Week 8	182.25 ± 45.55	163.71 ± 32.79	0.741b	0.557	0.459
Pb	0.164	0.903
LDL(mg/dl)
Week 0	115.03 ± 24.01	98.32 ± 29.35	0.007a
Week 8	107.96 ± 27.94	104.96 ± 29.22	0.194b	2.906	0.094
Pb	0.011	0.152
HbA1C (%)
Week 0	5.2(4.5–5.6)	4.9(4.5–5.6)	0.867a
Week 8	4.8(4.3–5.2)	5(4.6–5.6)	0.023b	8.674	0.005
Pb	0.024	0.174
Insulin(µU/mL)
Week 0	14.6(11.4–19.6)	9.3(3.9–17.2)	0.061a
Week 8	12.3(8.1–21.1)	9.1(4.9–16.3)	0.846b	0.303	0.584
Pb	0.479	0.336
HOMA-IR
Week 0	3.4(2.34-5)	2.2(0.7–4.3)	0.089a
Week 8	2.7(1.7–4.6)	1.9(1-4.1)	0.794b	1.078	0.304
Pb	0.217	0.128
QUICKI
Week 0	0.53(0.4–0.6)	0.56(0.5–0.7)	0.235a
Week 8	0.56(0.5–0.6)	0.6(0.5–0.7)	0.711b	0.089	0.767
Pb	0.870	0.447

Data are reported as mean ± SD for normally distributed variables and interquartile range for non-normally distributed variables

^a: Obtained from the independent t-test for normally distributed variables /Mann-Whitney test for other variables

^b:analysis of covariance adjusted for baseline values, smoking, education, and the change in energy intake for normally distributed variables/ Mann-Whitney test for changes in serum levels of non-normally distributed variables

P^b: Obtained from the paired sample t-test for normally distributed variables and Wilcoxon test for non-normally distributed variables

P-value c Obtained from repeated measures analysis of variance adjusted for smoking, education and the change in energy intake