Table 2.
Mortality | ICU admission | Length of hospital stay | Endotracheal intubation | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Subgroup criteria | Analysis type | RR (95% CI) | I2 | p value | RR (95% CI) | I2 | p value | MD (95% CI) | I2 | p value | RR (95% CI) | I2 | p value |
Total analysis | 0.72 (0.54–0.94) | 54% | 0.02 | 0.58 (0.38–0.88) | 74% | 0.01 | −1.00 (−2.16 to 0.16) | 63% | 0.13 | 0.78 (0.56–1.08) | 60% | 0.13 | |
Subgroup by administration method | Single-dose | 0.88 (0.69–1.12) | 21% | 0.3 | 0.79 (0.61–1.03) | 22% | 0.08 | −1.11 (−2.35 to 0.13) | 53% | 0.08 | −0.10 (−0.23 to 0.03) | 42% | 0.13 |
Continuous dose | 0.53 (0.34–0.83) | 55% | 0.006 | 0.44 (0.22–0.90) | 74% | 0.02 | −0.50 (−2.23 to 1.22) | 69% | 0.57 | −0.00 (−0.04 to 0.04) | 45% | 0.87 | |
Subgroup by dosage | ≥100,000 IU | 0.85 (0.71–1.02) | 1% | 0.07 | 0.86 (0.60–1.24) | 54% | 0.42 | −0.91 (−1.83 to 0.01) | 57% | 0.05 | 0.59 (0.32–1.09) | 38% | 0.09 |
<100,000 IU | 0.30 (0.21–0.44) | 0% | <0.0001 | 0.31 (0.21–0.47) | 0% | 0.001 | −0.97 (−3.24 to 1.29) | 48% | 0.4 | 0.96 (0.39–2.35) | 34% | 0.93 | |
Subgroup by baseline vitamin D status | Vitamin D deficient (25OHD < 30 ng/mL) | 0.73 (0.59–0.89) | 0% | 0.002 | 0.63 (0.42–0.93) | 0% | 0.02 | −0.62 (−2.17 to 0.92) | 72% | 0.43 | 0.92 (0.61–1.37) | 36% | 0.67 |
No baseline restriction | 0.73 (0.46–1.15) | 73% | 0.18 | 0.59 (0.32–1.11) | 86% | 0.1 | −0.25 (−1.12 to 0.62) | 75% | 0.57 | 0.78 (0.34–1.80) | 74% | 0.57 |