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The screen of 19 against JAK isozymes (IC50, nM).
| Compound | IC50a |
|||
|---|---|---|---|---|
| JAK1 | JAK2 | JAK3 | TYK2 | |
| 19 | 165 ± 13 | 278 ± 20 | > 10000 | 860 ± 33 |
| Filgotinib | 11.0 ± 0.32 | 28.6 ± 1.50 | 810 ± 45.0 | 116 ± 6.45 |
aWe ran experiments in duplicate, SD <15%. Assays were performed by Reaction Biology Corporation (Malvern, PA, USA).
