TABLE 3.
Comparison of model 2 and model 1 fitting to Z‐spectra data obtained at B1rms of 1.4 μT and duration of 2 seconds from gray matter tissue of human brain using Monte‐Carlo simulations
| Amplitude (%) | Width (ppm) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| DS | MT | rNOE | Cr‐w CEST | CEST@3.5 ppm | DS | MT | rNOE | Cr‐w CEST | CEST@3.5 ppm | ||
| Model 2 | Par0 | 52.22 | 36.51 | 10.38 | 6.22 | 7.09 | 2.31 | 45.12 | 5.27 | 1.99 | 3.39 |
| mean ± SD | 51.96 ± 1.61 | 38.38 ± 2.01 | 11.12 ± 1.68 | 6.86 ± 1.89 | 7.19 ± 1.73 | 2.30 ± 0.12 | 50.12 ± 3.65 | 5.51 ± 1.14 | 2.25 ± 0.90 | 3.60 ± 1.29 | |
| ARPE | 2.46 | 6.18 | 14.68 | 25.96 | 19.92 | 4.27 | 12.12 | 17.60 | 38.74 | 31.70 | |
| Model 1 | Par0 | 51.07 | 33.99 | 12.55 | 5.96 | 7.79 | 2.27 | 46.72 | 6.96 | 2.19 | 4.58 |
| mean ± SD | 50.55 ± 2.02 | 34.90 ± 2.42 | 13.97 ± 2.15 | 6.64 ± 2.16 | 8.04 ± 2.00 | 2.25 ± 0.13 | 53.75 ± 5.64 | 7.65 ± 1.79 | 2.46 ± 1.01 | 5.41 ± 2.02 | |
| ARPE | 3.33 | 6.06 | 17.15 | 29.55 | 20.79 | 4.56 | 16.13 | 22.66 | 41.70 | 37.97 |
Abbreviations: ARPE, average absolute relative percentage error; CEST@3.5 ppm, CEST contrast at 3.5 ppm; Cr‐w CEST, CEST contrast at 1.8 ppm; DS, direct saturation; MT, magnetization transfer; rNOE, relayed nuclear Overhauser effect; Par0, parameters obtained from fitting of Z‐spectra without noise; SD, standard deviation.