Fig. 2.

Retinotopic coding organizes spontaneous interaction between internally and externally oriented brain networks. A. Spatially-matched pRFs in dATNs and DNs. We assessed the influence of retinotopic coding on the interaction between internally- and externally-oriented brain areas’ spontaneous activity during resting-state fMRI, by comparing the correlation in activation between pRFs in these networks that represent similar regions of visual space. For each −DN pRF, we established the top 10 closest +dATN pRF voxels’ centers (“matched”) and the 10 furthest pRF centers (“antimatched”). In each resting-state fMRI scan, we extracted the average time series from −DN pRFs and correlated that time series with the average time series from the +dATN matched and antimatched pRFs. We repeated this procedure for all resting-state runs in all participants. Plot shows one example resting-state time series from a participant’s -DN, +dATN matched and +dATN antimatched pRFs and the associated correlation values. B. Spatially matched −DN/+dATN pRFs have a greater opponent interaction than anti-matched pRFs, showing that opponent dynamics depend on retinotopic preferences. Histogram shows the distribution in correlation values between matched (dark green) and antimatched (light green) pRF pairs for each resting-state run in all participants, which were significantly different (matched versus antimatched: D(392)=0.245, p<0.001). Bar plot shows the average correlation for each participant (matched versus anti-matched: t(6)=3.49, p=0.011). C. DN subnetworks A and B both evidenced a retinotopic opponent interaction (DN-A: t(6)=3.02, p=0.023, DN-B: t(6)=2.72, p=0.034; DN-A vs. DN-B: t(6)=1.64, p<0.15), although the opponency was stronger overall in DN-A compared to DN-B (difference in average correlation between −DN/+dATN pRFs: t(6)=5.41, p=0.002).