Figure 2. The Optokinetic Reflex (OKR) is Intact in Tau Transgenic Mice.

A. Schematic of the head-fixed experimental apparatus to measure the OKR (top). OKR was elicited with a virtual rotating striped drum. Image of the mouse pupil as captured during optokinetic stimulation (bottom). Arrow indicates the corneal reflection. N - nasal, T - temporal. B. Representative eye movement (black) in the horizontal (azimuth) elicited by sinusoidal rotation of the striped drum (green). C. Representative eye movement traces from one mouse in response to optokinetic stimulation at different temporal frequencies. D. Analysis of OKR gain (eye movement velocity/drum velocity) in 5-month-old WT and Tau mice (N=9 WT, 7 Tau mice; 0.2 Hz: p = 0.4183, 0.4 Hz: p = 0.6412, 0.6 Hz: p = 0.9955, 0.8 Hz: p = 0.9970, 1.0 Hz: p = 0.9750). Data is shown as mean +/−SEM.