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[Preprint]. 2024 Sep 28:2024.09.27.615429. [Version 1] doi: 10.1101/2024.09.27.615429

Fig. 2. The majority of cells bearing the Ki-67 proliferation marker are LANA+ in KS PDX tumors.

Fig. 2.

(A) IHC detection of the Ki-67 proliferation marker in a representative KS biopsy and matched PDX tumor; scale bars = 100 μm, and inset panels magnified 2X. (B) Percent Ki-67+ cells in IHC of biopsy/PDX pairs that were counted by automated quantification in HALO software; ***, p< 0.001, two-tailed paired t test. (C) IF staining for LANA (red) and Ki-67 (yellow), alone or in combination, in biopsy/PDX pair. DAPI (blue) in the merge panel; scale bars = 50 μm. (D) Left, quantification of IF shown in (C). (E), quantification of Ki-67+ relative to LANA+ cells and (F), quantification of LANA+ relative to Ki-67+ cells in seven additional biopsy/PDX pairs; **, p<0.01***, p< 0.001, two-tailed paired t test.