Table 1.

Experimental structures of integrin αVβ3 available in the Protein Data Bank

PDB ID	Method	Resolution (Å)	Year (PDB)	Ligand details				Ref.
				Name	Metal	Selectivity for αVβ3	Activity
1JV2	X-ray	3.10	2001	-	Ca2+			42
1L5G	X-ray	3.20	2002	Cyclic RGD peptide (Cilengitide)	Mn2+	Non-selective	Partial agonist	36
1M1X	X-ray	3.30	2002	-	Mn2+			36
1U8C	X-ray	3.10	2004	-	Ca2+			43
3IJE	X-ray	2.90	2009	-	Ca2+			44
4G1E	X-ray	3.00	2012	-	Ca2+			45
4G1M	X-ray	2.90	2012	-	Ca2+			45
4MMX	X-ray	3.32	2013	The tenth domain of fibronectin (wtFn10)	Mn2+	Selective	Agonist	34
4MMY	X-ray	3.18	2013	Fibronectin peptide (IAKGDWND motif)	Mn2+	Selective	Partial agonist	34
4MMZ	X-ray	3.10	2013	The antagonistic tenth domain of Fibronectin (hFn10)	Mn2+	Selective	Antagonist	34
4O02	X-ray	3.60	2013	αV-specific antibody (17E6).	Mn2+	Non-selective	Antagonist	40
6AVQ	Cryo-EM	35.00	2017	αVβ3 monoclonal antibody (LM609)	-	Selective	Antagonist	41
6AVR	Cryo-EM	35.00	2017	αVβ3 monoclonal antibody (LM609)	-	Selective	Antagonist	41
6AVU	Cryo-EM	35.00	2017	αVβ3 monoclonal antibody (LM609)	-	Selective	Antagonist	41
6MK0	X-ray	3.00	2019	Inhibitor TDI-4161	Mn2+	Selective	Antagonist	37
6MSL	X-ray	3.10	2019	Knottin EETI-II 2.5D	Mn2+	Selective	Partial agonist	39
6MSU	X-ray	3.11	2019	Knottin EETI-II 2.5F	Mn2+	Non-selective	Partial agonist	39
6NAJ	X-ray	3.10	2019	Hr10 variant of 10th domain of fibronectin	Mn2+		Antagonist	38