Feline Pit2 sequence. The predicted amino acid sequence of FePit2 is shown in single amino acid code. The sequence of HuPit2 is shown below for comparison, with a dot to indicate conserved residues. The putative transmembrane regions are indicated with a gray box, and an open box surrounds the proposed extracellular domains (9, 33, 61). Position 522, which has been shown to be important in determining HuPit2 receptor activity, is indicated in bold (10).