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. 2024 Sep 27;20(9):e1012179. doi: 10.1371/journal.ppat.1012179

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© 2024 Hickson, Hyde

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 7 — RNA from Vero cells infected with TC83 or TC83/E1_IDsyn (MOI of 0.1) was analyzed by SHAPE-MaP. (A) Differential SHAPE reactivities of nucleotides in E1. The central region responsible for enhanced macrophage replication of TC83/E1_IDsyn is highlighted in blue. Secondary structures and SHAPE reactivities of nucleotides in the central domain of (B) TC83 and (C) TC83/E1_IDsyn. Low reactive nucleotides (black) correspond to base-paired nucleotides and highly reactive nucleotides (orange, red) correspond to exposed bases. Structural elements conserved between both viruses are highlighted in grey, and SNPs are highlighted in blue.