FIG. 3.

Dependence of course of mortality on T-cell subset depletion 1 day before or 3, 6, or 10 days after mKSA cell challenge. Mice immunized by two i.p. injections of 10 μg of TAg on days −14 and −7 were depleted of CD4⁺, CD8⁺ or both T-lymphocyte populations. Depletion was achieved by i.v. injection of 500 μg of the respective MAb as a single dose on day −1, +3, +6, or +10 relative to challenge with 10⁶ mKSA cells on day 0. Tumor development and death of mice were monitored daily.