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. 2024 Jul 3;23(10):e14263. doi: 10.1111/acel.14263

FIGURE 1.

FIGURE 1

SAMP8 mice show significant memory deficits, decrease in balance and strength and weight loss throughout aging. Scatter plot with bar are mean ± standard error mean (SEM) of: (a) the discrimination index (DI) of SAMR1 and SAMP8 mice at 2.5, 6 and 9 months of age tested in the NORT (2.5 months: t 38 = 2504, p = 0.0167; 6 months t 26 = 2976 p = 0.0062); (b) latency (s) to cross the wooden beam (9 months: p = 0.0372 Mann–Whitney test) and (c) the number of foot slips for SAMR1 and SAMP8 tested in the beam walking test at 2.5, 6, and 9 months of age (6 months: *p = 0.0161; 9 months: **p = 0.0050 Mann–Whitney test); (d) mouse clinging latency on the grid in the paw grip test (2.5 months: ***p = 0.0009; 6 months: **p = 0.0187 Mann–Whitney's test). (e) Mean ± SEM of SAMR1 and SAMP8 mouse weight. Two‐way ANOVA found a significant interaction genotype × time F (4,152) = 7664, p < 0.0001; ***p < 0.001; ****p < 0.0001 Tukey's multiple comparisons test.