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. 2024 Jul 3;23(10):e14263. doi: 10.1111/acel.14263

FIGURE 2.

FIGURE 2

SAMP8 mouse brain shows growth defects throughout aging. Scatter plot with bar are mean ± SEM of cortical, hippocampal, striatum and whole brain volume of SAMR1 and SAMP8 at the three ages investigated. Statistical analysis carrying by comparing SAMP8 vs. SAMR1 at each single age revealed statistical significance for: Cortex (6 months) t 17 = 4043, p = 0.0008, (9 months) t 12 = 4497, p = 0.0007, Student's t‐test. Hippocampus (6 months) p = 0.0133, (9 months) p = 0.0020, Mann–Whitney's test. Striatum (9 months) t 12 = 2281, p = 0.0416 Student's t‐test. Whole brain (6 months) t 17 = 3583, p = 0.0023, (9 months) t 12 = 4248, p = 0.0011 Student's t‐test. Statistical analysis through a two‐way ANOVA for factors strain and time revealed a significant interaction: F (2,48) = 8.185, p = 0.0009 and a significant effect of age highlighting volume increase only for SAMR1 mice: F (2,48) = 13.08, p < 0.0001. *p < 0.05, **p < 0.001, ***p < 0.001, ****p < 0.001 (Student's t‐test; Šidàk's test).